Recombinant 小鼠 anti-人 IgE Antibody
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Quick Overview for Recombinant 小鼠 anti-人 IgE Antibody (ABIN7072336)
抗原
抗体类型
克隆类型
应用范围
克隆位点
亚型
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适用
- 人
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宿主
- 小鼠
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原理
- Anti-IgE [TES-C21], Mouse IgG1, kappa
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特异性
- The antibody binds specifically to IgE, an immunoglobulin isotype secreted by upon stimulation of B cells by interleukins Il-4 and IL-13. IgE provides immunity to parasites such as helminths and Plasmodium falciparum. The immunoglobulin also plays a central role in the development of Type I hypersensitivity reactions and allergic diseases such as asthma, sinusitis and food allergies. These allergic responses are triggered by the binding of IgE to the high affinity receptor FcεRI, expressed on the surface of basophils and mast cells. Binding of IgE causes cross-linking of the receptor, inducing degranulation and release of inflammatory mediators, particularly of histamine. The monoclonal antibody TES-C21 binds to secreted IgE and to IgE expressed on the surface of IgE-producing B cells, thereby inhibiting IgE binding to FcεRI and the release of histamine from mast cells. The monoclonal antibody can have diagnostic applications, such as for identifying and quantifying IgE-expressing B cells and IgE levels in serum samples, and therapeutic applications in the treatment of allergies. Furthermore, the antibody can conjugated to cytotoxic drugs and deliver them specifically to IgE-producing B cells.
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产品特性
- This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.
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纯化方法
- Protein A affinity purified
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免疫原
- Polyclonal human IgE.
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Mouse anti-Human IgE antibody
ELISA, FACS Monoclonal 4G7-325 IgG unconjugated
Mouse anti-Human IgE (Fc Region) antibody (Biotin)ELISA, WB, ELISpot Monoclonal HP6029 IgG2a Biotin
Mouse anti-Human IgE antibody (Biotin)ELISA, FACS Monoclonal BE5 IgG1 Biotin
Mouse anti-Human IgE antibodyELISA, WB, FACS Monoclonal 4H10 IgG1 unconjugated
Mouse anti-Human IgE antibodyELISA, FACS Monoclonal BE5 IgG1 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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OriginalSpeciesName: Mouse
OriginalFormat: IgG
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- IgE
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物质类
- Antibody
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背景
- Immunoglobulin E
抗原
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