兔 anti-人 Ig (Chain lambda), (Light Chain) Antibody
IHC (fro), IHC (p)
Polyclonal
unconjugated
产品编号 ABIN115330
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for 兔 anti-人 Ig (Chain lambda), (Light Chain) Antibody (ABIN115330)
抗原
Ig
克隆类型
多克隆
应用范围
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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抗原表位
- Chain lambda, Light Chain
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适用
- 人
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宿主
- 兔
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纯化方法
- Purified
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免疫原
- Lambda light chains isolated from pooled urine of patients with Bence Jones proteinuria
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应用备注
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Immunohistochemistry on formalin-fixed paraffin embedded sections: dilute 1: 250-1: 1000in an ABC method (incubation time: 30 minutes at room temperature). Recommended positive control: Tonsil
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Ig
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别名
- Immunoglobulin
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背景
- All five immunoglobulin classes share the same basic four polypeptide chain structure of two heavy-chains and two light chains. There are five heavy chain types, and two light-chain types (Kappa and Lambda) both having a molecular weight of 22.5 kDa. Any heavy-chain type can associate with either light-chain type, but on any immunoglobulin molecule both light-chains are of the same type. Kappa and Lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of Kappa to Lambda is 70:30 , the vast majority of which is bound to heavy-chain in immunoglobulin. In normal individuals low levels of free light-chain arepresent in serum (kappa, 1.6-15.2 mg/L, Lambda, 0.4-4.2 mg/L), with the occurrence of multiple myeloma or other B-cell malignancies these levels can be greatly elevated and can be found at high levels in the urine (Bence-Jones proteins).
抗原
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