This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009].
Sharan, Zhu, Xie, Li, Tang, Tang, Zhang, Xia: "Down-regulation of miR-206 is associated with Hirschsprung disease and suppresses cell migration and proliferation in cell models." in: Scientific reports, Vol. 5, pp. 9302, (2015) (PubMed).
Bastiani, Liu, Hill, Jedrychowski, Nixon, Lo, Abankwa, Luetterforst, Fernandez-Rojo, Breen, Gygi, Vinten, Walser, North, Hancock, Pilch, Parton: "MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes." in: The Journal of cell biology, Vol. 185, Issue 7, pp. 1259-73, (2009) (PubMed).
Hill, Bastiani, Luetterforst, Kirkham, Kirkham, Nixon, Walser, Abankwa, Oorschot, Martin, Hancock, Parton: "PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function." in: Cell, Vol. 132, Issue 1, pp. 113-24, (2008) (PubMed).