(Golgi Reassembly Stacking Protein 1, 65kDa (GORASP1))
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Several alternatively spliced transcript variants of this gene have been identified, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008].
Wang, Satoh, Warren: "Mapping the functional domains of the Golgi stacking factor GRASP65." in: The Journal of biological chemistry, Vol. 280, Issue 6, pp. 4921-8, (2005) (PubMed).
Lane, Lucocq, Pryde, Barr, Woodman, Allan, Lowe: "Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis." in: The Journal of cell biology, Vol. 156, Issue 3, pp. 495-509, (2002) (PubMed).
Marra, Maffucci, Daniele, Tullio, Ikehara, Chan, Luini, Beznoussenko, Mironov, De Matteis: "The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment." in: Nature cell biology, Vol. 3, Issue 12, pp. 1101-13, (2002) (PubMed).
Aliases for GORASP1 抗体
golgi reassembly stacking protein 1 (GORASP1) 抗体 golgi reassembly stacking protein 1 (gorasp1) 抗体 golgi reassembly stacking protein 1 (PTRG_03298) 抗体 golgi perepheral membrane protein p65 (PY00200) 抗体 golgi reassembly stacking protein 1 (Gorasp1) 抗体 golgi reassembly stacking protein 1a (gorasp1a) 抗体 5430411C10Rik 抗体 cb744 抗体 GOLPH5 抗体 GRASP65 抗体 MGC69226 抗体 MGC134531 抗体 P65 抗体 zgc:101588 抗体