This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012].
Belichenko, Madani, Rey-Bellet, Pihlgren, Becker, Plassard, Vuillermot, Giriens, Nosheny, Kleschevnikov, Valletta, Bengtsson, Linke, Maloney, Hickman, Reis, Granet, Mlaki, Lopez-Deber, Do, Singhal et al.: "An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. ..." in: PLoS ONE, Vol. 11, Issue 3, pp. e0152471, (2016) (PubMed).
Segawa, Otsuka, Itou, Suzuki, Karatani, Sakai: "Characterization of the circulating serum amyloid A in bottlenose dolphins." in: Veterinary immunology and immunopathology, Vol. 152, Issue 3-4, pp. 218-24, (2013) (PubMed).
Aliases for SAA 蛋白
serum amyloid A1 (SAA1) 蛋白 serum amyloid A (saa) 蛋白 serum amyloid A protein (LOC476879) 蛋白 serum amyloid A1 (SAA) 蛋白 serum amyloid A-3 (SAA3) 蛋白 HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 (HPS5) 蛋白 serum amyloid A2 (SAA2) 蛋白 serum amyloid A 1 (Saa1) 蛋白 serum amyloid A protein (LOC100270725) 蛋白 PIG4 蛋白 SAA 蛋白 saa 蛋白 Saa-1 蛋白 SAA1 蛋白 SAA2 蛋白 Saa2 蛋白 TP53I4 蛋白 zgc:103580 蛋白