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抗Human RHEB 抗体:
抗Mouse (Murine) RHEB 抗体:
抗Rat (Rattus) RHEB 抗体:
Human Polyclonal RHEB Primary Antibody for IHC, ELISA - ABIN1003087
Yamagata, Sanders, Kaufmann, Yee, Barnes, Nathans, Worley: rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. in The Journal of biological chemistry 1994
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Human Polyclonal RHEB Primary Antibody for ELISA, WB - ABIN1003086
Yee, Worley: Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals. in Molecular and cellular biology 1997
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Human Monoclonal RHEB Primary Antibody for ELISA, WB - ABIN519784
Menon, Dibble, Talbott, Hoxhaj, Valvezan, Takahashi, Cantley, Manning: Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. in Cell 2014
Human Polyclonal RHEB Primary Antibody for WB - ABIN2476356
Kageyama, Takahashi: Pepsinogens and pepsins from gastric mucosa of Japanese Monkey. Purification and characterization. in Journal of biochemistry 1976
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FADD (显示 FADD 抗体) interference down-regulated Rheb expression and repressed mTORC1 activity in breast cancer cell lines. The autophagy was induced by FADD (显示 FADD 抗体) deficiency in MCF7 or MDA-231 cells but rescued by recovering Rheb expression.
Describe a novel interaction between Rheb and the tumor suppressor RASSF1A. This interaction may allow coordinate upregulation of Hippo while TOR is suppressed to modulate the balance of apoptosis and autophagy in lung tumor cells.
activation of mTOR (显示 FRAP1 抗体) signalling via RHEB over-expression inhibited the starvation-induced autophagy but did not affect trafficking of tf-Amyloid precursor protein (APP (显示 APP 抗体)). These results show tf-APP (显示 APP 抗体) can be used to determine how APP (显示 APP 抗体) is trafficked through the lysosomal system of the cell.
Data suggest DNM2 (显示 DNM2 抗体)/RRAGB (显示 RRAGB 抗体)- (or DNM2 (显示 DNM2 抗体)/RRAGC (显示 RRAGC 抗体)-)dependent endocytosis of extracellular amino acids (AAs (显示 FGD1 抗体)) plays critical role in mTORC1 transport/activation; recruitment of mTORC1 from cytoplasm to lysosome is suppressed by DNM2 (显示 DNM2 抗体) inhibition; AA deprivation appears to be main cause of mTORC1 inactivation via DNM2 (显示 DNM2 抗体) inhibition. (RHEB = Ras homolog enriched in brain; DNM2 (显示 DNM2 抗体) = dynamin II (显示 DNM2 抗体); RRAG = Ras-related GTP binding protein (显示 RAB10 抗体))
By interfering with TSC (显示 SLC12A3 抗体)-Rheb complex, arginine relieves allosteric inhibition of Rheb by TSC (显示 SLC12A3 抗体). Arginine cooperates with growth factor signaling which further promotes dissociation of TSC2 (显示 TSC2 抗体) from lysosomes and activation of mTORC1.
Data show that Rheb/p27 (显示 PAK2 抗体) axis induces autophagy-dependent cancer cell survival under stress conditions.
Mutations in the TSC2 (显示 TSC2 抗体)-RHEB-mTOR (显示 FRAP1 抗体) signaling axis may lead to a loss of inhibitory inputs thus conferring a survival advantage to a dividing tumor cell.
Activation of CNTF (显示 CNTF 抗体)/CNTFRalpha (显示 CNTFR 抗体) signaling pathway by hRheb(S16H) transduction of dopaminergic neurons
RGS10 (显示 RGS10 抗体) could serve in a novel, and previously unknown, role by accelerating the hydrolysis of GTP (显示 AK3 抗体) from Rheb in ovarian cancer cells.
In TSC2 (显示 TSC2 抗体)-deficient angiomyolipoma patient cells, IRF7 (显示 IRF7 抗体) is a pivotal factor in the Rheb/mTOR (显示 FRAP1 抗体) pathway.
Thus, the various regulatory elements that impinge upstream of mTORC1 activation pathways are differentially required for HSC (显示 FUT1 抗体) homeostasis in vivo.
Forebrain depletion of Rheb GTPase (显示 RACGAP1 抗体) elicits spatial memory deficits.
Rheb is an important negative regulator of beige (显示 LYST 抗体) fat development and thermogenesis. Rheb is able to suppress the beiging effect through an mTORC1-independent mechanism, via PDE4D5-dependent downregulation of the cAMP-PKA signaling pathway.
Rheb and TSC2 (显示 TSC2 抗体) have roles in the mechanical activation of mTOR (显示 FRAP1 抗体) signaling
EAAT4 (显示 SLC1A6 抗体) was downregulated due to the loss of Rheb1 in Purkinje cells; mTORC1 was downregulated and Akt (显示 AKT1 抗体) was upregulated in Rheb1 cKO mice, suggesting that mTORC1 and Akt (显示 AKT1 抗体) may be related to the downregulation of EAAT4 (显示 SLC1A6 抗体); Rheb1 knockout decreased EAAT4 (显示 SLC1A6 抗体) currents and slowed down the kinetics of AMPA (显示 GRIA3 抗体) currents; Rheb1 deficiency did not affect the morphology of Purkinje cell layer and the development of Purkinje cells
Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.
Rheb activation disrupts neuronal spine synapse formation via syntenin (显示 SDCBP 抗体) accumulation in tuberous sclerosis complex.
We conclude that in contrast to TORC1 (显示 CRTC1 抗体) hyper-activity, cognitive function is not very sensitive to sustained and specific down-regulation of TORC1 (显示 CRTC1 抗体) activity.
Rheb protein was mainly detected in apoptotic retinal ganglion cells following light injury.
PDK4 (显示 PDK4 抗体) promotes tumorigenesis through activation of the CREB (显示 CREB1 抗体)-RHEB-mTORC1 signaling cascade.
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.
Ras homolog enriched in brain
, RAS-homolog enriched in brain
, ras homolog enriched in brain
, GTP-binding protein rheb
, GTP-binding protein Rheb
, Ras homolog enriched in brain 2