(RNA Guanylyltransferase and 5'-Phosphatase (RNGTT))
Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
Trotman, Agana, Giltmier, Wysocki, Schoenberg: "RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome." in: The Journal of biological chemistry, Vol. 293, Issue 43, pp. 16596-16607, (2018) (PubMed).
Housden, Valvezan, Kelley, Sopko, Hu, Roesel, Lin, Buckner, Tao, Yilmazel, Mohr, Manning, Perrimon: "Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi." in: Science signaling, Vol. 8, Issue 393, pp. rs9, (2015) (PubMed).
Mukherjee, Bakthavachalu, Schoenberg: "The cytoplasmic capping complex assembles on adapter protein nck1 bound to the proline-rich C-terminus of Mammalian capping enzyme." in: PLoS biology, Vol. 12, Issue 8, pp. e1001933, (2014) (PubMed).