RNF7 抗体
(Ring Finger Protein 7 (RNF7))
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Latest Publications for our RNF7 抗体
: "Hunting for serine 276-phosphorylated p65." in: Journal of biomedicine & biotechnology, Vol. 2010, pp. 275892, (2010) (PubMed).: "E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification." in: Molecular cell, Vol. 33, Issue 4, pp. 483-95, (2009) (PubMed).
: "CXCL5 promotes prostate cancer progression." in: Neoplasia (New York, N.Y.), Vol. 10, Issue 3, pp. 244-54, (2008) (PubMed).
: "Toll-like receptor 2 mediates apolipoprotein CIII-induced monocyte activation." in: Circulation research, Vol. 103, Issue 12, pp. 1402-9, (2008) (PubMed).
: "Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase." in: Science (New York, N.Y.), Vol. 284, Issue 5414, pp. 657-61, (1999) (PubMed).
: "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity." in: Molecular cell, Vol. 3, Issue 4, pp. 535-41, (1999) (PubMed).
: "Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34." in: Genes & development, Vol. 13, Issue 12, pp. 1614-26, (1999) (PubMed).
Aliases for RNF7 抗体
ring finger protein 7 (RNF7) 抗体ring finger protein 7 (Rnf7) 抗体
CKBBP1 抗体
Rbx2 抗体
ROC2 抗体
SAG 抗体
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