This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome. [provided by RefSeq, Sep 2011].
Li, Guan, Huang, Hu, Zheng: "RNF168-mediated H2A neddylation antagonizes ubiquitylation of H2A and regulates DNA damage repair." in: Journal of cell science, Vol. 127, Issue Pt 10, pp. 2238-48, (2014) (PubMed).
Patel, Garikapati, Pandita, Singh, Pandita, Bhadra, Bhadra: "miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin." in: Scientific reports, Vol. 7, Issue 1, pp. 4263 (PubMed).
Aliases for RNF168 抗体
ring finger protein 168 (Rnf168) 抗体 ring finger protein 168, E3 ubiquitin protein ligase L homeolog (rnf168.L) 抗体 ring finger protein 168 (RNF168) 抗体 3110001H15Rik 抗体 hRNF168 抗体