E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP- ribosylated proteins (By similarity).
Xu, Luo, Zhao, Zhao, Yang, Chen, Huo, Han, Fei: "Iduna protects HT22 cells from hydrogen peroxide-induced oxidative stress through interfering poly(ADP-ribose) polymerase-1-induced cell death (parthanatos)." in: Cellular signalling, Vol. 25, Issue 4, pp. 1018-26, (2013) (PubMed).
Kang, Lee, Shin, Andrabi, Chi, Gagné, Lee, Ko, Lee, Poirier, Dawson, Dawson: "Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 34, pp. 14103-8, (2011) (PubMed).
Aliases for RNF146 抗体
ring finger protein 146 (RNF146) 抗体 ring finger protein 146 (Rnf146) 抗体 RING finger protein 146 (rn146) 抗体 ring finger protein 146 S homeolog (rnf146.S) 抗体 ring finger protein 146 (rnf146) 抗体 2610509H23Rik 抗体 dactylidin 抗体 dJ351K20.1 抗体 Iduna 抗体 RNF146 抗体 rnf146 抗体 RP3-351K20.1 抗体 wu:fi29e08 抗体 zgc:55909 抗体