The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008].
ring finger protein 139 (RNF139) 蛋白 ring finger protein 139 (Rnf139) 蛋白 ring finger protein 139 (rnf139) 蛋白 ring finger protein 139 S homeolog (rnf139.S) 蛋白 4930555P18Rik 蛋白 HRCA1 蛋白 RCA1 蛋白 rnf139 蛋白 TRC8 蛋白 zgc:175173 蛋白