The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Aliases for RNF128 抗体
ring finger protein 128a (rnf128a) 抗体 ring finger protein 128, E3 ubiquitin protein ligase (RNF128) 抗体 ring finger protein 128 (Rnf128) 抗体 ring finger protein 128, E3 ubiquitin protein ligase (Rnf128) 抗体 ring finger protein 128, E3 ubiquitin protein ligase L homeolog (rnf128.L) 抗体 1300002C13Rik 抗体 AI987883 抗体 GRAIL 抗体 grail 抗体 Greul1 抗体 greul1 抗体 RGD1566282 抗体 rnf128 抗体 wu:fb57h05 抗体 zgc:77843 抗体