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抗Mouse (Murine) PUM2 抗体:
抗Rat (Rattus) PUM2 抗体:
抗Human PUM2 抗体:
Human Polyclonal PUM2 Primary Antibody for IP, WB - ABIN151851
Masutomi, Possemato, Wong, Currier, Tothova, Manola, Ganesan, Lansdorp, Collins, Hahn: The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. in Proceedings of the National Academy of Sciences of the United States of America 2005
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Cow (Bovine) Polyclonal PUM2 Primary Antibody for WB - ABIN2779082
Hynes, Calder, Rosenfeld, Scott: The use of tranexamic acid to reduce blood loss during total hip arthroplasty: an observational study. in Annals of the Royal College of Surgeons of England 2005
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Human Polyclonal PUM2 Primary Antibody for ELISA, WB - ABIN250404
Szakmary, Cox, Wang, Lin: Regulatory relationship among piwi, pumilio, and bag-of-marbles in Drosophila germline stem cell self-renewal and differentiation. in Current biology : CB 2005
major role of Pum1 (显示 PUM1 抗体) and Pum2 in hippocampal neurogenesis and function
These results argue for a role of Pum2 in epileptogenesis and the maintenance of epilepsy.
Pum2 serves key functions in the adult mammalian central nervous system encompassing neuronal excitability and behavioral response to environmental challenges
PUM2 binds to AChE mRNA and regulates AChE expression translationally at the neuromuscular synapse.
P2P-R (显示 RBBP6 抗体) expression may be translationally regulated by PUM2
Data show that Pumilio-2 is expressed most abundantly in germ cells with the highest expression in undifferentiated gonocytes and spermatogonia.
1.6A resolution X-ray crystal structure of the Puf (显示 NME1 抗体) domain from murine Pum2 was presented.
SAM68 (显示 KHDRBS1 抗体) is required for efficient recruitment of PUM2 to NORAD, regulation of Pum (显示 MYOD1 抗体) activity by NORAD, and proper chromosome segregation in mammalian cells.
A recent paper by the Mendell group identifies NORAD, a novel lncRNA that is regulated in response to DNA damage and plays a key role in maintaining genome integrity by modulating the activity the RNA binding proteins PUM2 and PUM1 (显示 PUM1 抗体).
results reveal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1 (显示 PUM1 抗体)/2 and FOXP1 (显示 FOXP1 抗体) in regulating normal hematopoietic stem/progenitor cell and leukemic cell growth.
The study shows that pseudouridine and N(6)-methyladenosine weaken the binding of the human single-stranded RNA binding protein (显示 PTBP1 抗体) Pumilio 2 (hPUM2) to its consensus motif.
Pumilios (including PUM1 (显示 PUM1 抗体) and PUM2) are RNA-binding proteins with Puf domains made up of 8 poorly conserved Puf repeats, 3 helix bundles arranged in rainbow architecture, where each repeat recognizes a single base of the RNA-binding sequence. [REVIEW]
Identification of NORAD-interacting proteins revealed that this lncRNA functions as a multivalent binding platform for PUM (显示 MYOD1 抗体) proteins, with the capacity to sequester a significant fraction of the total cellular pool of PUM1 (显示 PUM1 抗体) and PUM2. Studies reveal unanticipated roles for a lncRNA and PUMILIO proteins in the maintenance of genomic stability.
PUM2 does not repress differentiation of adipose-derived stem cells (ASCs) but rather is involved in the positive control of ASCs division and proliferation.
human Pumilio homologs Pum 1 and Pum 2 repress the translation of E2F3 by binding to the E2F3 3' untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs (miRNAs)
Mammalian PUM2-Ago-eEF1A (显示 EEF1A1 抗体) inhibited translation of nonadenylated and polyadenylated reporter mRNAs in vitro.
NANOS1 (显示 NANOS1 抗体)-PUMILIO2 complex, together with GEMIN3 (显示 DDX20 抗体) and small noncoding RNAs, possibly regulate mRNA translation within the chromatoid body of the human germ cells.
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts (By similarity).
, pumilio homolog 2
, pumilio 2