This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011].
ras homolog family member G (Rhog) 蛋白 ras homolog family member Gb (rhogb) 蛋白 ras homolog family member G (RHOG) 蛋白 ras homolog family member G S homeolog (rhog.S) 蛋白 ras homolog gene family, member Gd (rhogd) 蛋白 2810426G09Rik 蛋白 Arhg 蛋白 ARHG 蛋白 arhg 蛋白 rhog 蛋白 rhoga 蛋白 Sid10750 蛋白 wu:fk30f01 蛋白 zgc:55848 蛋白 zgc:66008 蛋白