This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
Schwartz, Tessema, Buranda, Pylypenko, Rak, Simons, Surviladze, Sklar, Wandinger-Ness: "Flow cytometry for real-time measurement of guanine nucleotide binding and exchange by Ras-like GTPases." in: Analytical biochemistry, Vol. 381, Issue 2, pp. 258-66, (2008) (PubMed).
Aliases for RHOC 蛋白
ras homolog family member C L homeolog (rhoc.L) 蛋白 ras homolog family member C (RHOC) 蛋白 ras homolog family member C (rhoc) 蛋白 ras homolog family member C (Rhoc) 蛋白 AI324259 蛋白 ARH9 蛋白 Arh9 蛋白 ARHC 蛋白 Arhc 蛋白 CRHOC 蛋白 H9 蛋白 LOC100221682 蛋白 RHOH9 蛋白