(RANBP2-Like and GRIP Domain Containing 5 (RGPD5))
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined. [provided by RefSeq, Jul 2008].
Brass, Dykxhoorn, Benita, Yan, Engelman, Xavier, Lieberman, Elledge: "Identification of host proteins required for HIV infection through a functional genomic screen." in: Science (New York, N.Y.), Vol. 319, Issue 5865, pp. 921-6, (2008) (PubMed).