Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity).
Castro, Campos, Babcock, Armijo, Martínez-Conde, Pincheira, Quilliam: "M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells." in: Journal of cellular biochemistry, Vol. 113, Issue 4, pp. 1253-64, (2012) (PubMed).
Vigil, Martin, Williams, Yeh, Campbell, Der: "Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34729-40, (2010) (PubMed).