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RFWD2 蛋白

(Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1 (By similarity).

7 results

custom-made RFWD2 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7555202
 
custom-made RFWD2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7565184
 
RFWD2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
产品编号 ABIN1317872
 
custom-made RFWD2 宿主: 小鼠 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS
产品编号 ABIN3137447
 
custom-made RFWD2 宿主: 人 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS
产品编号 ABIN3095004
 
RFWD2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN2730790
 
RFWD2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN2730791
 
  • 类型 Protein
    • Protein
  • 应用范围
    • ELISA
    • Western Blotting (WB)
    • Antibody Production (AbP)
    • SDS-PAGE (SDS)
    • Standard (STD)
    • Affinity Purification (AP)
    • Antibody Array (AA)
  • 适用
    • Human
    • Mouse
  • 图像
  • Carrier free only
  • 抗体来源
    • HEK-293 Cells
    • Cell-free protein synthesis (CFPS)
    • Wheat germ
  • 抗原表位
    • AA 1-731
    • AA 1-733
    • AA 632-731
    • Transcript Variant 1
    • Transcript Variant 2
  • 标记
    • His tag
    • Myc-DYKDDDDK Tag
    • Strep Tag
    • GST tag
  • 蛋白类型
    • Recombinant
  • Format
    • Liquid
  • Grade
    • custom-made
  • Supplier
    • antibodies-online
    • OriGene

Aliases for RFWD2 蛋白

ring finger and WD repeat domain 2 (RFWD2) 蛋白
ring finger and WD repeat domain 2 (Rfwd2) 蛋白
ring finger and WD repeat domain 2, E3 ubiquitin protein ligase (rfwd2) 蛋白
ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog (rfwd2.L) 蛋白
ring finger and WD repeat domain 2 (rfwd2) 蛋白
AI316802 蛋白
C80879 蛋白
COP1 蛋白
Cop1 蛋白
cop1 蛋白
RFWD2 蛋白
RGD1304773 蛋白
RNF200 蛋白
rnf200 蛋白
zgc:163067 蛋白
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