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抗Mouse (Murine) Corin 抗体:
抗Human Corin 抗体:
抗Rat (Rattus) Corin 抗体:
Human Polyclonal Corin Primary Antibody for IF (p), IHC (p) - ABIN872360
Sari, Rufaut, Jones, Sinclair: Characterization of Ovine Dermal Papilla Cell Aggregation. in International journal of trichology 2016
Show all 2 Pubmed References
Polyclonal Corin Primary Antibody for IHC (fro), IP - ABIN541078
Gladysheva, Robinson, Houng, Kováts, King: Corin is co-expressed with pro-ANP and localized on the cardiomyocyte surface in both zymogen and catalytically active forms. in Journal of molecular and cellular cardiology 2007
Data suggest that soluble corin lacking transmembrane domain is activated by PCSK6 in conditioned medium or in cell-free system but not intracellularly; cell membrane association is unnecessary for PCSK6 to activate corin; soluble corin and PCSK6 are secreted by cardiomyocytes (or HEK293 cells) via different intracellular pathways. (PCSK6 = proprotein convertase subtilisin/kexin type-6)
Suggest that pro-ANP/corin/NPR-C signaling is dominant in the vascular system in preeclampsia.
These results indicate that genetic variants impairing corin function are not uncommon in general populations and that such variants may be an important contributing factor in hypertension.
Preeclampsia is one of the most severe complications of the pregnancy, and trials to estimate a panel of predictive markers are of big interest for multiple researches. Corin is a transmembrane serine protease, localized in the heart, which is converting pro-ANP in to active ANR. ANP is a hormone regulating salt hemostasis and arterial blood pressure. [review]
Corin is a key enzyme in the natriuretic peptide system. The latest findings indicate that corin-mediated ANP production may act in a tissue-specific manner to regulate cardiovascular and renal function. Corin defects may contribute to major diseases such as hypertension, heart failure, pre-eclampsia, and kidney disease.
association of 2 single nucleotide polymorphisms in CORIN (rs2271037 and rs3749585) with hypertension, as well as their potential interactions with some risk factors of hypertension in a Han population of northeastern China
We detected elevated serum corin levels in women with pre-eclampsia. Interestingly, the serum corin levels were also found to be elevated in pregnancies with a related disorder, unexplained fetal growth restriction without hypertension, suggesting that this phenomenon is not simply a response to maternal hypertension.
Corin and atrial natriuretic peptide A were most abundant in the proximal convoluted tubules and the medullary connecting ducts.
CORIN expression is significantly downregulated in human masticatory mucosa during wound healing
serum levels of corin are significantly decreased in acute myocardial infarction patients
Data show that both furin and brain type natriuretic peptide (BNP) were more sensitive than corin in predicting cardiovascular complications in type 2 diabetes mellitus (T2DM) patients.
Circulating corin concentrations are related to infarct size in patients after ST-segment elevation myocardial infarction
Hypertensive participants had an increased serum corin level compared to those without hypertension, suggesting that corin may play a role in the pathology of hypertension.
Serum soluble corin was significantly and positively associated with dyslipidemia
Plasma corin levels decreased significantly from preoperative concentrations after coronary artery bypass graft surgery.
corin may play an important role in the pathology of atrial fibrillation
Increased serum soluble corin in mid pregnancy was associated with an increased risk for HDP(hypertensive disorders of pregnancy) .--increased serum soluble corin in mid pregnancy could be an indicator for HDP
identified a PCSK6 mutation that impaired corin activation activity in a hypertensive patient
the variant altered corin structure and impaired the natriuretic peptide processing activity in vivo. The results highlight corin defects as an important underlying mechanism in hypertension.
IRE1-dependent corin mRNA decay is a mechanism leading to corin protein deficiency may contribute to the pathophysiology of impaired natriuretic peptide pro-hormone processing in humans processing in humans with advanced systolic heart failure.
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.
corin, serine peptidase
, novel protein similar to H.sapiens CORIN, corin, serine peptidase (CORIN)
, atrial natriuretic peptide-converting enzyme-like
, atrial natriuretic peptide-converting enzyme
, low density lipoprotein receptor-related protein 4
, low density lipoprotein-related protein 4
, pro-ANP-converting enzyme
, heart-specific serine proteinase ATC2
, transmembrane protease serine 10