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抗Mouse (Murine) Corin 抗体:
抗Human Corin 抗体:
抗Rat (Rattus) Corin 抗体:
Human Polyclonal Corin Primary Antibody for IF (p), IHC (p) - ABIN872360
Sari, Rufaut, Jones, Sinclair: Characterization of Ovine Dermal Papilla Cell Aggregation. in International journal of trichology 2016
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Residues Lys (显示 LYZ 抗体)-71, Phe-72 and Gln-73 serve as a novel retention motif in the intracellular pathway to regulate corin cell surface expression and activation.
N-glycans at different sites may play distinct roles in regulating the cell membrane targeting, zymogen activation, and ectodomain shedding of corin
These results provide the first experimental evidence that corin expression plays a role in cardiomyopathy by modulating myocardial fibrosis, cardiac function, heart failure, and survival.
Data show that KO/TgV mice had significantly higher levels of proatrial natriuretic peptide in the heart compared with that in control KO/TgWT mice, indicating that the corin variant was defective in processing natriuretic peptides in vivo.
Lack of corin in mice impairs their adaptive renal response to high dietary salt, suggesting that corin deficiency may represent an important mechanism underlying salt-sensitive hypertension.
results indicate that corin and ANP (显示 NPPA 抗体) are essential for physiological changes at the maternal-fetal interface, suggesting that defects in corin and ANP (显示 NPPA 抗体) function may contribute to pre-eclampsia
Data indicate that Corin's involvement in ANP (显示 NPPA 抗体) processing is a key element in the heart's response to increased hemodynamic load
Ectodomain shedding and autocleavage of the cardiac membrane protease corin.
corin might be involved in the salt retention seen in glomerular diseases.
Insufficient corin activation is expected to prevent natriuretic peptide processing and may contribute to body fluid retention and impaired cardiac function in patients with heart failure.
Data suggest that soluble corin lacking transmembrane domain is activated by PCSK6 (显示 PCSK6 抗体) in conditioned medium or in cell-free system but not intracellularly; cell membrane association is unnecessary for PCSK6 (显示 PCSK6 抗体) to activate corin; soluble corin and PCSK6 (显示 PCSK6 抗体) are secreted by cardiomyocytes (or HEK293 cells) via different intracellular pathways. (PCSK6 (显示 PCSK6 抗体) = proprotein convertase subtilisin/kexin type-6 (显示 PCSK6 抗体))
Suggest that pro-ANP (显示 NPPA 抗体)/corin/NPR-C (显示 NPR3 抗体) signaling is dominant in the vascular system in preeclampsia.
These results indicate that genetic variants impairing corin function are not uncommon in general populations and that such variants may be an important contributing factor in hypertension.
Preeclampsia is one of the most severe complications of the pregnancy, and trials to estimate a panel of predictive markers are of big interest for multiple researches. Corin is a transmembrane serine protease (显示 F2 抗体), localized in the heart, which is converting pro-ANP (显示 NPPA 抗体) in to active ANR. ANP (显示 NPPA 抗体) is a hormone regulating salt hemostasis and arterial blood pressure. [review]
Corin is a key enzyme in the natriuretic peptide system. The latest findings indicate that corin-mediated ANP (显示 NPPA 抗体) production may act in a tissue-specific manner to regulate cardiovascular and renal function. Corin defects may contribute to major diseases such as hypertension, heart failure, pre-eclampsia, and kidney disease.
association of 2 single nucleotide polymorphisms in CORIN (rs2271037 and rs3749585) with hypertension, as well as their potential interactions with some risk factors of hypertension in a Han population of northeastern China
We detected elevated serum corin levels in women with pre-eclampsia. Interestingly, the serum corin levels were also found to be elevated in pregnancies with a related disorder, unexplained fetal growth restriction without hypertension, suggesting that this phenomenon is not simply a response to maternal hypertension.
Corin and atrial natriuretic peptide (显示 NPPA 抗体) A (显示 NPPA 抗体) were most abundant in the proximal convoluted tubules and the medullary connecting ducts.
CORIN expression is significantly downregulated in human masticatory mucosa during wound healing
serum levels of corin are significantly decreased in acute myocardial infarction patients
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.
corin, serine peptidase
, novel protein similar to H.sapiens CORIN, corin, serine peptidase (CORIN)
, atrial natriuretic peptide-converting enzyme-like
, atrial natriuretic peptide-converting enzyme
, low density lipoprotein receptor-related protein 4
, low density lipoprotein-related protein 4
, pro-ANP-converting enzyme
, heart-specific serine proteinase ATC2
, transmembrane protease serine 10