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抗Human SOX8 抗体:
抗Rat (Rattus) SOX8 抗体:
抗Mouse (Murine) SOX8 抗体:
Human Polyclonal SOX8 Primary Antibody for ELISA, WB - ABIN449560
ODonnell, Hong, Huang, Delnicki, Saint-Jeannet: Functional analysis of Sox8 during neural crest development in Xenopus. in Development (Cambridge, England) 2006
Suggest that miRNA-124 may regulate non-small cell lung carcinoma cell proliferation via decreasing SOX8.
SOX8 mRNA levels decrease during in vitro dedifferentiation of human articular chondrocytes and increase during chondrogenic differentiation of mesenchymal stromal cells.
SOX8 promotes cancer cell proliferation and its expression is correlated with elevated beta-catenin (显示 CTNNB1 抗体) levels in hepatocellular carcinoma
The SOX8 single nucleotide polymorphism, rs2744148, is associated with increased genetic risk for multiple sclerosis.
Quantitative changes of enteric glia represented by SOX8 provide a basis for pathological assessment of glial proliferation and/or degeneration in the diseased gut (显示 GUSB 抗体).
SOX2 (显示 SOX2 抗体) and SOX17 (显示 SOX17 抗体) expression patterns can distinguish between seminoma and embryonal carcinoma, and this distinction may be diagnostically useful.
Both Sox8 and Sox10 (显示 SOX10 抗体) are jointly required for myelin maintenance and myelin gene expression.
In this study characterized novel neuronal expression of the SoxE (显示 SOX10 抗体) factor, Sox8, specifically within striatal projection neurons of the embryonic and postnatal mouse striatum.
Concluding, this study shows that, in addition to its crucial role in testis development, Sox9 (显示 SOX9 抗体), together with Sox8 and coordinately with Dmrt1 (显示 DMRT1 抗体), also controls adult testis maintenance.
Binding of mrhl RNA to the Sox8 promoter is accompanied by the assembly of other regulatory factors involving Myc (显示 MYC 抗体)-Max-Mad transcription factors, corepressor Sin3a (显示 SIN3A 抗体), and coactivator Pcaf (显示 KAT2B 抗体)
These results suggest that Sox8 is essential in Sertoli cells for germ cell differentiation, partly by controlling the microenvironment of the seminiferous epithelium.
combined RNA profiling signals, motif predictions and network data identified putative SOX8/SOX9 (显示 SOX9 抗体) target genes in Sertoli cells and yielded insight into regulatory interactions that depend upon these transcription factors
Sox9 (显示 SOX9 抗体) and Sox8 maintain integrity of the basal lamina to prevent testis cord disintegration and both factors actively suppress the ovarian program during early testis development.
Seven regions near the Sox8 gene as potential enhancers, were identified.
SOX8 has a role in testis differentiation in mice and synergizes with SF1 (显示 SF1 抗体) to activate the Amh (显示 AMH 抗体) promoter in vitro
Sox8 acts as a specific negative regulator of skeletal muscle differentiation, possibly by interfering with the function of myogenic basic helix-loop-helix proteins
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).
transcription factor SOX-8
, SRY-box containing gene 8
, transcription factor Sox-8
, SOX8 transcription factor