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Human Polyclonal SOX8 Primary Antibody for ELISA - ABIN548047
ODonnell, Hong, Huang, Delnicki, Saint-Jeannet: Functional analysis of Sox8 during neural crest development in Xenopus. in Development (Cambridge, England) 2006
SOX8 bounds to the promoter region of FZD7 and induces the FZD7-mediated activation of the Wnt/beta-catenin pathway and confers chemoresistance and stemness properties and mediates epithelial mesenchymal transition in chemoresistant tongue squamous cell carcinoma.
Suggest that miRNA-124 may regulate non-small cell lung carcinoma cell proliferation via decreasing SOX8.
SOX8 mRNA levels decrease during in vitro dedifferentiation of human articular chondrocytes and increase during chondrogenic differentiation of mesenchymal stromal cells.
SOX8 promotes cancer cell proliferation and its expression is correlated with elevated beta-catenin levels in hepatocellular carcinoma
The SOX8 single nucleotide polymorphism, rs2744148, is associated with increased genetic risk for multiple sclerosis.
Quantitative changes of enteric glia represented by SOX8 provide a basis for pathological assessment of glial proliferation and/or degeneration in the diseased gut.
SOX2 and SOX17 expression patterns can distinguish between seminoma and embryonal carcinoma, and this distinction may be diagnostically useful.
Both Sox8 and Sox10 are jointly required for myelin maintenance and myelin gene expression.
In this study characterized novel neuronal expression of the SoxE factor, Sox8, specifically within striatal projection neurons of the embryonic and postnatal mouse striatum.
Concluding, this study shows that, in addition to its crucial role in testis development, Sox9, together with Sox8 and coordinately with Dmrt1, also controls adult testis maintenance.
Binding of mrhl RNA to the Sox8 promoter is accompanied by the assembly of other regulatory factors involving Myc-Max-Mad transcription factors, corepressor Sin3a, and coactivator Pcaf
These results suggest that Sox8 is essential in Sertoli cells for germ cell differentiation, partly by controlling the microenvironment of the seminiferous epithelium.
combined RNA profiling signals, motif predictions and network data identified putative SOX8/SOX9 target genes in Sertoli cells and yielded insight into regulatory interactions that depend upon these transcription factors
Sox9 and Sox8 maintain integrity of the basal lamina to prevent testis cord disintegration and both factors actively suppress the ovarian program during early testis development.
Seven regions near the Sox8 gene as potential enhancers, were identified.
SOX8 has a role in testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro
Sox8 acts as a specific negative regulator of skeletal muscle differentiation, possibly by interfering with the function of myogenic basic helix-loop-helix proteins
Results suggest that Sox8 reinforces Sox9 function in testis differentiation of mice.
Sox8-deficient mice thus exhibited a similar, but less severe phenotype than did Sox10-deficient mice wiwth regard to oligodendrocyte differentiation.
The defects in enteric nervous system development of mice with Sox10 and Sox8 mutations are caused by a reduction of the pool of undifferentiated vagal neural crest cells.
Sox8 is a negative regulator of osteoblast differentiation.
We analyzed SOX8 expression in developing mouse and chick brain, focused on the cerebellum. Sox8 appeared both in oligodendrocytes and astrocytes.
Loss of Sox8 did not impair oligodendrocyte specification
The ability of Sox8 to rescue the defects in enteric nervous system development and oligodendrocyte differentiation of Sox10-deficient mice is limited.
SOX8 transactivated genes have key roles in adult Sertoli-cell function and its elimination results in progressive male infertility.
SOX8 is a critical regulator of adult Sertoli cell function and is required for both its cytoarchitectural and paracrine interactions with germ cells.
This study shows that testis cord differentiation is independent of Sox9, and that concerted Sox9 and Sox8 function in post E14.0 Sertoli cells is essential for the maintenance of testicular function.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).
transcription factor SOX-8
, SRY-box containing gene 8
, transcription factor Sox-8
, SOX8 transcription factor