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A novel mutation of g.482G>T in RCAN1 may be related to congenital heart diseases by causing overexpression of RCAN1.
RCAN1.4 plays a novel role in regulating endothelial cell migration by establishing endothelial cell polarity in response to VEGF.
Lycopene inhibits RCAN1-mediated apoptosis by reducing ROS levels and by inhibiting NF-kappaB activation, Nucling induction, and the increase in apoptotic indices in neuronal cells.
Overexpression of RCAN1 markedly reduced glioma cells viability.
RCAN1.4 prevents cell proliferation, migration, and invasion in vitro; overexpressed RCAN1.4 in HCC cells prevents growth, angiogenesis, and metastases of xenograft tumors by inhibiting calcineurin activity and nuclear translocation of NFAT1.
elucidated a novel function of regulator of calcineurin 1 isoform 1 in mitochondria and provides a molecular basis for the regulator of calcineurin 1 isoform over-expression-induced mitochondrial dysfunctions and neuronal apoptosis
our research revealed that RCAN1 was involved in the development of small cell lung cancer, and it might be a cancer-inhibiting gene for the formation of bone metastases in small cell lung cancer
The results of the study indicate that RCAN1 is suppressed in endothelial cells of chronically inflamed periodontal tissues. During an acute infection, however, rcan1 seems to be upregulated in endothelial cells, indicating a modulating role in immune homeostasis of periodontal tissues.
mRNA expression levels of DSCR1 and VEGF-C, and microvessel density are increased in cancerous tissues, compared with paracancerous tissue in hypopharyngeal cancer.
The objective of this study was aimed to detect the association of Down syndrome critical region 1 (DSCR1) gene polymorphisms (rs149048873 and rs143081213) and congenital heart disease (CHD) susceptibility.
Results support overexpression of RCAN1 and particularly the RCAN1.1S isoform during aging as a pathogenic mechanism in both Down syndrome-related and sporadic Alzheimer's disease
RCAN1 can interact with IkappaBalpha and affect the phosphorylation of IkappaBalpha at tyrosine 42.
The sequence variations in RCAN1 promoter are not major genetic factors involved in sporadic CHD, at least in the current research population.
For DSCR1rs6517239, patients with an AA genotype had higher recurrence probability than patients carrying at least one allele G (37 +/- 4% SE vs. 15 +/- 6% SE) (HR: 0.51; 95% CI, 0.27-0.94; P = 0.027).
E4BP4 and BIM regulation correlated with that of RCAN1-1. A putative GRE and four EBPREs were identified within 1500bp upstream from the transcription start site of RCAN1-1
The transcriptional regulation of RCAN1.1 and RCAN1.4 by two alternative promoters, is reported.
Rcan1-1L may play a protective role in Ang II-treated cardiomyocytes through the induction of mitochondrial autophagy, and may be an alternative method of cardiac protection.
Results show that Rcan1 isoform 1L (Rcan1-1L) overexpression specifically activates mitophagy and increases cell survival under hypoxic conditions.
Data show that after IL-1beta treatment, the levels of reactive oxygen species and interleukin 8 (IL-8) mRNA of Down syndrome candidate region-1 (DSCR1)-transfected cells treated without BAPTA was significantly lower than those in pcDNA-transfected cells.
Study showed that RCAN1 further contributes to Alzheimer's disease pathogenesis by increasing N-glycosylation and Abeta production
RCAN1-regulated vascular branching which may play a role in the patterning of morphologically different vasculature.
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
Down syndrome candidate region 1
, Down syndrome critical region gene 1
, calcium and oxidant-inducible mRNA
, down syndrome critical region protein 1
, modulatory calcineurin-interacting protein 1
, myocyte-enriched calcineurin-interacting protein 1
, near DSCR proline-rich protein
, calcipressin 1
, down syndrome critical region protein 1 homolog
, regulator of calcineurin 1
, Down syndrome critical region homolog 1
, calcineurin inhibitor
, myocyte-enriched calcineurin interactin protein 1
, Down syndrome critical region protein 1 homolog
, Oxidative-induced protein Adapt78