This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008].
Kim, Kim, Jeon, Kim, Kim, Bae, Jung: "Prognostic implication of histological features associated with EHD2 expression in papillary thyroid carcinoma." in: PLoS ONE, Vol. 12, Issue 3, pp. e0174737, (2017) (PubMed).
Guilherme, Soriano, Furcinitti, Czech: "Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes." in: The Journal of biological chemistry, Vol. 279, Issue 38, pp. 40062-75, (2004) (PubMed).