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抗Human MED26 抗体:
抗Mouse (Murine) MED26 抗体:
抗Rat (Rattus) MED26 抗体:
EAF1 (显示 SRCAP 抗体) (239-268) and TAF7 (显示 TAF7 抗体) (205-235) peptide interactions were both mapped to the same groove formed by H3 and H4 helices of MED26 N-terminal domain.
the MED26-NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7 (显示 TAF7 抗体)) for LEC to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes
MED26 can function as a molecular switch that interacts first with TFIID (显示 TBP 抗体) in the Pol II (显示 Pol II 抗体) initiation complex and then exchanges TFIID (显示 TBP 抗体) for complexes containing ELL (显示 ELL 抗体)/EAF and P-TEFb (显示 CCNT1 抗体) to facilitate transition of Pol II (显示 Pol II 抗体) into the elongation stage of transcription.
Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation
findings identify MED19 (显示 MED19 抗体)/MED26 as a probable composite REST interface in Mediator and further clarify the mechanistic basis by which Mediator facilitates REST-imposed epigenetic restrictions on neuronal gene expression
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
mediator of RNA polymerase II transcription subunit 26
, CRSP complex subunit 7
, mediator complex subunit 26
, activator-recruited cofactor 70 kDa component
, cofactor required for Sp1 transcriptional activation subunit 7
, cofactor required for Sp1 transcriptional activation, subunit 7 (70kD)
, cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa
, transcriptional coactivator CRSP70
, solute carrier family 35, member E1
, CRSP70-like protein