TXK tyrosine Kinase ELISA Kit

3 products by 3 suppliers: Abbexa | RayBiotech | Wuhan Fine biotech
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96 tests
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Relevance Score uniqeid Catalogue Id Detection Method Sample Type Analytical Method Detection Range Sensitivity Supplier References Quantity Price
6.5 element-ABIN5696699 ABIN5696699 Colorimetric
Quantitative Sandwich ELISA 0.31 ng/mL - 20 ng/mL 0188 ng/mL Log in to see
  • (1)
96 tests $641.23
6 element-ABIN6229243 ABIN6229243 Colorimetric
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6 element-ABIN4886333 ABIN4886333 Colorimetric
Cell Lysate, Tissue Lysate Semi-Quantitative Sandwich ELISA Log in to see
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TXK Antigen Profile

Antigen Summary

Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.

Alternative names and synonyms associated with TXK

  • TXK tyrosine kinase (TXK) ELISA Kit
  • TXK tyrosine kinase (Txk) ELISA Kit
  • tyrosine-protein kinase TXK (LOC100544958) ELISA Kit
  • PTK4 ELISA Kit
  • A130089B16Rik ELISA Kit
  • Btkl ELISA Kit
  • Rlk ELISA Kit

Protein level used designations for TXK

PTK4 protein tyrosine kinase 4 , protein-tyrosine kinase 4 , resting lymphocyte kinase , tyrosine kinase , tyrosine-protein kinase TXK , PTK-RL-18 , TXK tyrosine kinase , tyrosine-protein kinase TXK-like , LOW QUALITY PROTEIN: tyrosine-protein kinase TXK

7294 Homo sapiens
22165 Mus musculus
305311 Rattus norvegicus
444993 Sus scrofa
461344 Pan troglodytes
482139 Canis lupus familiaris
504782 Bos taurus
705104 Macaca mulatta
770387 Gallus gallus
100019276 Monodelphis domestica
100054343 Equus caballus
100341671 Oryctolagus cuniculus
100397226 Callithrix jacchus
100455862 Pongo abelii
100464564 Ailuropoda melanoleuca
100544958 Meleagris gallopavo
100598060 Nomascus leucogenys
100722451 Cavia porcellus