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抗Human GNAT1 抗体:
抗Rat (Rattus) GNAT1 抗体:
抗Mouse (Murine) GNAT1 抗体:
Data suggest that a hetero-multimer complex forms between light-activated rhodopsin (显示 RHO 抗体) and light-activated heterotrimeric transducin (T-alpha-1, Gnb1 (显示 GNB1 抗体), Gngt1 (显示 GNGT1 抗体)); the stoichiometry is 1:1 rhodopsin:transducin. The complex appears to form on native rod outer segment membranes upon light activation.
These results indicated that efficient Gt activation by rhodopsin (显示 RHO 抗体), resulting from an optimized active state of rhodopsin (显示 RHO 抗体), is one of the causes of the high amplification efficiency of rods.
These data suggest that some truncating GNAT1 variants can indeed cause a recessive, mild, late-onset retinal degeneration in human beings rather than just stationary night-blindness as reported previously.
Three candidate tumor-suppressor genes, SEMA3B (显示 SEMA3B 抗体), AXUD1 (显示 CSRNP1 抗体) and GNAT1 may be involved in oral squamous cell carcinoma.
These data suggest that a homozygous missense mutation in GNAT1 is associated with autosomal recessive stationary night blindness.
Expression of GNAT1 gene is down-regulated or absent in nasopharyngeal carcinoma tissues.
Data suggest light reduces oxygen consumption rate (OCR) of retina; light does not affect OCR in retinas of Gnat1-/- knockout mice (phototransduction disabled). Light reduces cGMP in retina; light does not alter cGMP in Gnat1-/- plus Gnat2 (显示 GNAT2 抗体)-/- retina.
Biochemical changes, including reduced transducin protein levels and enhanced transducin GTPase (显示 RACGAP1 抗体) activity, explain the shift in light intensity threshold for Galphat1 translocation in Rs1 (显示 RS1 抗体)-knockout mice.
The results from shaker1 and whirler (显示 DFNB31 抗体) mice suggest that defective transducin translocation may be functionally related to light-induced degeneration.
ectopically expressed cTalpha (显示 PCYT1A 抗体) 1) forms a heterotrimeric complex with rod Gbeta (显示 SUCLG2 抗体)(1)gamma(1), and substitutes equally for rTalpha in generating photoresponses initiated by either rhodopsin (显示 RHO 抗体) or S-cone opsin (显示 RHO 抗体)
Oligomerization incompetent retinal degeneration slow (显示 PRPH2 抗体) is associated with mislocalization of cone opsins and cone transducin.
Data show that visual responses in TKO (显示 MRPS12 抗体) mice extend beyond the retina to encompass the lateral margins of the lateral geniculate nucleus and components of the visual cortex.
Thus our results showed that IRD1 and IRD2 mice harbor a nonsense mutation in the Gnat1 gene, resulting in the absence or suppressed expression of the Tralpha protein, which is the likely cause of rod dysfunction in both mutants.
alpha-transducin can function in taste receptor cells and transduce some taste cell responses
data suggest that phosducin (显示 PDC 抗体) action is based on the reduction of transducin affinity to the membranes of rod outer segments, achieved by keeping the transducin beta gamma subunits apart from the alpha subunit (显示 POLG 抗体).
Alpha-transducin played no role in regulating adaptive response to light. Degeneration does not require transducin-mediated signaling.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
guanine nucleotide-binding protein G(t) subunit alpha-1
, rod-type transducin alpha subunit
, guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
, guanine nucleotide binding protein, alpha transducing activity polypeptide 1
, guanine nucleotide-binding protein G(t) subunit alpha-1-like
, transducin alpha-1 chain
, guanine nucleotide-binding protein G(T), alpha-1 subunit
, transducin, rod-specific
, guanine nucleotide binding protein (G protein), alpha transducing 1
, guanine nucleotide binding protein, alpha transducing 1
, Galpha t1
, rod transducin alpha subunit
, transducin alpha (rod)
, rod photoreceptor transducin alpha 1 subunit
, transducin alpha subunit GNAT1