anti-EGR1 (EGR1) 抗体产品概述

Human Early Growth Response 1 (EGR1) interaction partners

1. miR-181 serves an important role during renal fibrosis by targeting Egr1.

2. This study describes the identification of a splicing isoform for the human EGR1 gene. The newly identified splicing transcript encodes a shorter protein compared to the canonical EGR1. This isoform lacks a region belonging to the N-terminal activation domain and although it is capable of entering the nucleus, it is unable to activate transcription fully relative to the canonical isoform.

3. miR-181a-5p is a negative regulator of Egr1 that can suppress tumor proliferation in HCC through targeting Egr1/TGF-beta1/Smad pathway, which may be a potential therapeutic approach of HCC.

4. these data demonstrated the negative effect of up-regulated GCN5 in IL-6-induced metastasis and EMT in prostate cancer (PCa) cells through PI3K/PTEN/Akt signaling pathway down-regulating Egr-1 expression.

5. The results reveal a novel role for ZF3 domain in the interaction of Egr-1 with other proteins and the DNA, providing insight on the regulation of other genes by Egr-1.

6. Androgen receptor is crucial for dampening prostate tissue factor expression via nuclear factor-kappaB and early growth response protein 1 pathway.

7. results revealed AGE-mediated activation of EGR-1 and its downstream genes via PKC betaII and ERK1/2 signaling pathway. The present study demonstrated a novel mechanism of AGEs/ PKC betaII/ ERK1/2/EGR-1 pathway in inducing vascular inflammation in GDM.

8. a novel BCR-ABL1 protein kinase-dependent pathway mediated by the upregulation of hsa-mir183, the downregulation of its direct target early growth response 1 (EGR1), and, as a consequence, upregulation of E2F1.

9. these data suggested that the elevated cav-1 promoted pituitary adenoma cells migration and invasion by regulating the interaction between EGR1 and KLF5.

10. BAG3 may have an important role in HGF-mediated cell proliferation and metastasis in gastric cancer through an ERK and Egr1-dependent pathway.

11. miR-203 decreased the proliferation, invasion, and ECM production of keloid fibroblasts by repressing EGR1 and FGF2 expression.

12. SRF may control cell proliferation and invasion by regulating Egr1 in cervical cancer.

13. Hyperglycemic induction of Egr-1 and absence of NAB-2 repression in retinal endothelium, up-regulates downstream genes involved in pro-thrombotic and pro-inflammatory pathways linking Egr-1 to diabetes mediated vascular aberration of retina.

14. CacyBP expression is regulated by E2F1, EGR1, and CREB transcription factors in colorectal cancer HCT116 cells.

15. The differential binding of transcription factor EGR1 to the SNP rs5751348 genomic region with the different genotypes in the A4GALT gene leads to differential activation of P(1) -A4GALT and P(2) -A4GALT expression.

16. High EGR1 expression is associated with thyroid cancer progression.

17. Egr-1 regulates mindin expression by directly binding to the mindin promoter; mindin suppresses colon cancer progression by blocking angiogenesis.

18. The novel EGR1-CCND1 axis contributes to the G1 phase arrest and cell proliferation in glioma

19. we determined that REC8 interacted with EGR1, and inhibited EMT in gastric cancer cells. We thus propose further studies of the pathways associated with REC8 and EGR1 to potentially find novel targets in the treatment for gastric cancer.

20. ATF3 and EGR1 are involved in the beginning of inflammatory processes. Whether these two transcription factors act as tumour suppressors or promoters is context dependent and warrants analysis in further studies

Mouse (Murine) Early Growth Response 1 (EGR1) interaction partners

1. Egr-1 deletion delayed tumor development in vivo mouse models and decreased the rate of cell growth in vitro in tumor cell lines derived from breast tumors developed in each mouse.

2. Androgen receptor is crucial for dampening prostate tissue factor expression via nuclear factor-kappaB and early growth response protein 1 pathway.

3. The Zn complex plays a significant role in the protein-DNA binding of operator DNA by Egr-1.

4. estrogen induces transcription factor EGR1 to regulate c-Kit transcription for uterine receptivity for embryo implantation in the mouse uterus.

5. Study shows that EGR-1 is involved in the regulation of the expression of the voltage-gated Ca(2+) channel CaValpha2delta-1 subunit.

6. Tet1 overexpression affected adult neurogenesis with oligodendrocyte differentiation in the hippocampal dentate gyrus of Tet1-TG mice. In addition, Tet1 overexpression induced the elevated expression of immediate early genes, such as Egr1, c-fos, Arc, and Bdnf, followed by the activation of intracellular calcium signals in prefrontal and hippocampal neurons.

7. Our study provides strong evidence that Egr1 is a transcriptional activator of NOX4 in oxidative stress of DKD. Egr1 contributes to diabetic kidney disease by enhancing EMT, in part by targeting NOX4.

8. these results revealed that EGR-1 appears to facilitate VACV replication in starved fibroblasts by affecting viral particles infectivity.

9. EGR1-deficient mice displayed a reduced locomotor activity and altered temperature regulation. EGR1-deficient mice displayed disrupted activity rhythm with no measurable endogenous period length. The daily rhythm of BMAL1 mRNA was completely abolished in the EGR1-deficient mice.

10. Egr1(-/-) mice on the C57BL/6 background have normal eyelid development, but back-crossing to BALB/c background for four or five generations resulted in defective eyelid development by day E15.5.

11. Data (including date from studies in knockout mice) suggest that EGR1 is essential in response of airway epithelium to urban pollution/particulate matter (PM); particulate matter induces rapid up-regulation of expression of EGR1 in human bronchial epithelial cells and of Egr1 in mouse lungs. Egr1 knockout mice exhibit significantly reduced airway inflammation and mucus hyper-production in response to PM exposure in vivo.

12. Early growth response protein 1 regulates promoter activity of alpha-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system

13. ATF3 inhibit the expression and release of TNF-alpha, IL-1beta, IL-6, and IL-18 induced by Mycoplasma pneumonia in vitro and in vivo, which is associated with its negative regulation of Egr-1/Fyn signaling pathway.

14. Egr-1 deficiency attenuates NF-kappaB and TGFbeta-mediated renal inflammation/fibrosis.

15. miR-301b promotes the proliferation, migration, and aggressiveness of human bladder cancer cells by inhibiting the expression of EGR1

16. Egr-1 upregulation is characteristic of the cardiovascular disease pathogenesis. (Review)

17. Low EGR1 expression is associated with cardiac ischemia and systolic dysfunction.

18. Herein, we report that silencing of Egr-1 in the hippocampus by shRNA reduces tau phosphorylation, lowers amyloid-beta (Abeta) pathology, and improves cognition in the 3xTg-Alzheimer disease mouse model.

19. Egr-1 is a novel regulator of drebrin expression, which is linked to changes in dendritic spine density

20. In the present study, we have investigated the contribution of element C to Krox20 expression, as it was the only characterized initiator element with an activity in r3. Using a conditional knock-out mutation of element C, we show that, unexpectedly, this element is not necessary for Krox20 initial expression in r3.

Cow (Bovine) Early Growth Response 1 (EGR1) interaction partners

1. This is the first study to reveal that bta-miR-2361 as a novel host factor regulates Bovine herpesvirus 1 replication via directly targeting the EGR1 gene.

2. EGR1 is a major upstream component of FGF signaling in theca cells and that it directs cell fate toward proliferation.

3. Suggest that EGR1 is likely an upstream component of FGF signaling in granulosa cells.

4. EGR1 can promote skeletal muscle satellite cell differentiation through positive regulation of MyoG gene expression.

5. Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.

6. The authors conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells.

7. EGR-1's expression prior to ovulation and its stimulating effect on the expression of genes known to be involved in prostaglandin biosynthesis pathway, suggest its potential involvement in the regulation of preovulatory events in cattle.

Pig (Porcine) Early Growth Response 1 (EGR1) interaction partners

1. Egr-1 silencing through intracoronary delivery of a targeting DNAzyme at the time of reperfusion following acute myocardial ischemia decreases myocardial inflammation and apoptosis leading to improved cardiac function.

2. Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion.

Rabbit Early Growth Response 1 (EGR1) interaction partners

1. Gene therapy using in vivo transfection of an Egr-1 decoy ODN significantly inhibits proliferation of VSMC and intimal hyperplasia of vein grafts in a rabbit model.

2. Results show that EGR1 plays a key role in tendon formation, healing, and repair through BMP12/Smad1/5/8 pathway.

3. Collectively, these results demonstrate that Egr-1 is expressed rapidly upon HSV-1 infection and that this novel induction could be due to the NFsmall ka, CyrillicB/CREB-mediated transactivation.

Zebrafish Early Growth Response 1 (EGR1) interaction partners

1. egr1 colocalizes with tyrosine hydroxylase in the olfactory bulb throughout brain development.

2. successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish

3. The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization

4. Egr1 gene has important role in zebrafish embryonic oculogenesis. Lens and retina with egr1 gene deletion were primitive and lacked differentiation. Such arrested retinal and lenticular development in Egr1 morphants resulted in microphthalmos.

Rhesus Monkey Early Growth Response 1 (EGR1) interaction partners

1. Investigation of EGR1 indicates that its downregulation in simian immunodeficiency virus encephalitis may occur as a consequence of the host response to infection, leading to deficits in cognition.