(RNA Binding Motif Protein, Y-Linked Family 1 Member A1 (RBMY1A1))
This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2\; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008].
Dreumont, Bourgeois, Lejeune, Liu, Ehrmann, Elliott, Stévenin: "Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2-{beta}." in: Journal of cell science, Vol. 123, Issue Pt 1, pp. 40-50, (2009) (PubMed).
Skrisovska, Bourgeois, Stefl, Grellscheid, Kister, Wenter, Elliott, Stevenin, Allain: "The testis-specific human protein RBMY recognizes RNA through a novel mode of interaction." in: EMBO reports, Vol. 8, Issue 4, pp. 372-9, (2007) (PubMed).
Lavery, Glennon, Houghton, Nolan, Egan, Maher: "Investigation of DAZ and RBMY1 gene expression in human testis by quantitative real-time PCR." in: Archives of andrology, Vol. 53, Issue 2, pp. 71-3, (2007) (PubMed).