This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011].
Jackson, Du, Janesko-Feldman, Vagni, Dezfulian, Poloyac, Jackson, Clark, Kochanek: "The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 35, Issue 4, pp. 655-66, (2015) (PubMed).
Aliases for RBM5 抗体
RNA binding motif protein 5 (rbm5) 抗体 RNA binding motif protein 5 S homeolog (rbm5.S) 抗体 RNA binding motif protein 5 (RBM5) 抗体 RNA binding motif protein 5 L homeolog (rbm5.L) 抗体 RNA binding motif protein 5 (Rbm5) 抗体 D030069N10Rik 抗体 g15 抗体 G15 抗体 h37 抗体 luca15 抗体 LUCA15 抗体 rbm5 抗体 RBM5 抗体 rmb5 抗体 RMB5 抗体 wu:fc25a08 抗体 wu:fe06f12 抗体