This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011].
Sui, Yang, Xiong, Zhang, Blanchard, Peiper, Dynan, Tuan, Ko: "Gene amplification and associated loss of 5' regulatory sequences of CoAA in human cancers." in: Oncogene, Vol. 26, Issue 6, pp. 822-35, (2007) (PubMed).