(Ras Association (RalGDS/AF-6) Domain Family Member 5 (RASSF5))
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Yang, Kong, Jin, Hergovich, Püschel: "Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway." in: Journal of cell science, Vol. 127, Issue Pt 16, pp. 3463-76, (2014) (PubMed).
Gezginci-Oktayoglu, Bolkent: "Ras signaling in NGF reduction and TNF-α-related pancreatic β cell apoptosis in hyperglycemic rats." in: Apoptosis : an international journal on programmed cell death, Vol. 17, Issue 1, pp. 14-24, (2012) (PubMed).
Miertzschke, Stanley, Bunney, Rodrigues-Lima, Hogg, Katan: "Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration." in: The Journal of biological chemistry, Vol. 282, Issue 42, pp. 30629-42, (2007) (PubMed).
Aliases for RASSF5 抗体
Ras association domain family member 5 (RASSF5) 抗体 Ras association (RalGDS/AF-6) domain family member 5 (Rassf5) 抗体 Ras association domain family member 5 (Rassf5) 抗体 1300019G20Rik 抗体 AU042887 抗体 Maxp1 抗体 NORE1 抗体 Nore1 抗体 NORE1A 抗体 Nore1A 抗体 NORE1B 抗体 Nore1B 抗体 RAPL 抗体 Rapl 抗体 RASSF3 抗体