The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008].
Bai, Wang, Huo, Xie, Xie, Xu, Wang: "Serine/Threonine Kinase CHEK1-Dependent Transcriptional Regulation of RAD54L Promotes Proliferation and Radio Resistance in Glioblastoma." in: Translational oncology, Vol. 11, Issue 1, pp. 140-146, (2018) (PubMed).
Li, Xie, Wang, Li, Wang: "CDC7-dependent transcriptional regulation of RAD54L is essential for tumorigenicity and radio-resistance of glioblastoma." in: Translational oncology, Vol. 11, Issue 2, pp. 300-306, (2018) (PubMed).
Tang, Deng, Bai, Sun, Neale, Wu, Wang, Chang, Huang, Zhang, Li, Xiao, Cao, Tao, Yang: "Reduced expression of DNA repair genes and chemosensitivity in 1p19q codeleted lower-grade gliomas." in: Journal of neuro-oncology, Vol. 139, Issue 3, pp. 563-571, (2018) (PubMed).
Srivastava, Modi, Tripathi, Mudgal, De, Sengupta: "BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54." in: Journal of cell science, Vol. 122, Issue Pt 17, pp. 3093-103, (2009) (PubMed).
Aliases for RAD54L 抗体
RAD54 like (RAD54L) 抗体 RAD54 like (S. cerevisiae) (Rad54l) 抗体 RAD54 like (Rad54l) 抗体 RAD54 like (rad54l) 抗体 RAD54-like (S. cerevisiae) (RAD54L) 抗体 GdRAD54 抗体 hHR54 抗体 HR54 抗体 hRAD54 抗体 MGC69368 抗体 RAD54 抗体 RAD54-like 抗体 RAD54A 抗体 rad54l 抗体 RAD54L 抗体 zgc:56289 抗体