This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009].
Haynes, Gajan, Nangia-Makker, Shekhar: "RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence." in: Biochimica et biophysica acta. Molecular basis of disease, Vol. 1866, Issue 1, pp. 165561, (2020) (PubMed).
Zhang, Kang, Gou, Wang, Xue, Skogerboe, Dai, Huang, Chen, Fu, Liu, He: "MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes." in: Cell research, Vol. 25, Issue 2, pp. 193-207, (2016) (PubMed).
Aliases for RAD1 抗体
RAD1 checkpoint DNA exonuclease (RAD1) 抗体 RAD1 checkpoint DNA exonuclease (Rad1) 抗体 RAD1 homolog (S. pombe) (rad1) 抗体 RAD1 checkpoint DNA exonuclease (rad1) 抗体 DKFZp459H1127 抗体 HRAD1 抗体 RAD1 抗体 REC1 抗体 xrad1 抗体 zgc:56502 抗体 zgc:77779 抗体