RABGEF1 forms a complex with rabaptin-5 (RABPT5\; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A\; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010].
Lucitti, Sealock, Buckley, Zhang, Xiao, Dudley, Faber: "Variants of Rab GTPase-Effector Binding Protein-2 Cause Variation in the Collateral Circulation and Severity of Stroke." in: Stroke, Vol. 47, Issue 12, pp. 3022-3031, (2016) (PubMed).
Saito, Murai, Kajiho, Kontani, Kurosu, Katada: "A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5." in: The Journal of biological chemistry, Vol. 277, Issue 5, pp. 3412-8, (2002) (PubMed).
Rubino, Miaczynska, Lippé, Zerial: "Selective membrane recruitment of EEA1 suggests a role in directional transport of clathrin-coated vesicles to early endosomes." in: The Journal of biological chemistry, Vol. 275, Issue 6, pp. 3745-8, (2000) (PubMed).
Horiuchi, Lippé, McBride, Rubino, Woodman, Stenmark, Rybin, Wilm, Ashman, Mann, Zerial: "A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function." in: Cell, Vol. 90, Issue 6, pp. 1149-59, (1997) (PubMed).