Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway (By similarity).
custom-made
RAB7B
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
custom-made
RAB7B
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
Rab7b, member RAS oncogene family (Rab7b) 蛋白 rab7B protein (rab7B) 蛋白 RAB7B, member RAS oncogene family (RAB7B) 蛋白 RAB7B, member RAS oncogene family S homeolog (rab7b.S) 蛋白 RAB7B, member RAS oncogene family (rab7b) 蛋白 RAB7B, member RAS oncogene family (Rab7b) 蛋白 RAB7 蛋白 RAB7B 蛋白 Rab7b 蛋白 RGD1562617 蛋白