RAB7B 抗体
(RAB7B, Member RAS Oncogene Family (RAB7B))
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway (By similarity).
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Latest Publications for our RAB7B 抗体
: "Rab7a regulates cell migration through Rac1 and vimentin." in: Biochimica et biophysica acta, Vol. 1864, Issue 2, pp. 367-381, (2016) (PubMed).: "A novel interaction between Rab7b and actomyosin reveals a dual role in intracellular transport and cell migration." in: Journal of cell science, Vol. 127, Issue 22, pp. 4927-39, (2014) (PubMed).
: "Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells." in: Molecular biology of the cell, Vol. 22, Issue 10, pp. 1699-715, (2011) (PubMed).
: "GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation." in: Journal of neurochemistry, Vol. 115, Issue 2, pp. 423-37, (2010) (PubMed).
: "Rab7b controls trafficking from endosomes to the TGN." in: Journal of cell science, Vol. 123, Issue Pt 9, pp. 1480-91, (2010) (PubMed).
: "SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery." in: Molecular biology of the cell, Vol. 20, Issue 4, pp. 1223-40, (2009) (PubMed).
: "Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease." in: Journal of neuropathology and experimental neurology, Vol. 68, Issue 9, pp. 994-1005, (2009) (PubMed).
: "Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells." in: Biochemical and biophysical research communications, Vol. 318, Issue 3, pp. 792-9, (2004) (PubMed).
Aliases for RAB7B 抗体
Rab7b, member RAS oncogene family (Rab7b) 抗体rab7B protein (rab7B) 抗体
RAB7B, member RAS oncogene family (RAB7B) 抗体
RAB7B, member RAS oncogene family S homeolog (rab7b.S) 抗体
RAB7B, member RAS oncogene family (rab7b) 抗体
RAB7B, member RAS oncogene family (Rab7b) 抗体
RAB7 抗体
RAB7B 抗体
Rab7b 抗体
RGD1562617 抗体
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