(RAB11 Family Interacting Protein 2 (Class I) (RAB11FIP2))
A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA). Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.
Sakai, Fukuda, Unida, Aki, Ono, Endo, Kusumi, Koga, Fukushima, Komada, Okiyoneda: "The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors." in: Journal of cell science, Vol. 132, Issue 3, (2019) (PubMed).
Schafer, Baetz, Lapierre, McRae, Roland, Goldenring: "Rab11-FIP2 interaction with MYO5B regulates movement of Rab11a-containing recycling vesicles." in: Traffic (Copenhagen, Denmark), Vol. 15, Issue 3, pp. 292-308, (2014) (PubMed).
Aliases for RAB11FIP2 抗体
RAB11 family interacting protein 2 (Rab11fip2) 抗体 RAB11 family interacting protein 2 (RAB11FIP2) 抗体 RAB11 family interacting protein 2 (class I) (Rab11fip2) 抗体 4930470G04Rik 抗体 A830046J09Rik 抗体 AW558126 抗体 nRip11 抗体 Nrip11 抗体 Rab11-FIP2 抗体 RGD1308538 抗体