This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
Aliases for Purine-Rich Element Binding Protein B 蛋白
purine rich element binding protein B (Purb) 蛋白 purine-rich element binding protein Bb (purbb) 蛋白 purine-rich element binding protein B L homeolog (purb.L) 蛋白 purine rich element binding protein B (PURB) 蛋白 purine-rich element binding protein Ba (purba) 蛋白 2310015K15Rik 蛋白 AA114818 蛋白 Cager-2 蛋白 D11Bwg0414e 蛋白 pur-beta 蛋白 purb 蛋白 purb-b 蛋白 purbeta 蛋白 PURBETA 蛋白 si:dkey-202n14.1 蛋白 zgc:65916 蛋白