(Prostaglandin E Receptor 1 (Subtype EP1), 42kDa (PTGER1))
The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008].
Takemiya, Takeuchi, Kawakami: "Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4⁺ T Cells through IL-1β Autocrine Function in Experimental Autoimmune Encephalomyelitis." in: International journal of molecular sciences, Vol. 18, Issue 12, (2018) (PubMed).
Li, He, Ma, Yu, Bhave, Lentz, Tan, Guzman, Zhao, Xue: "Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1." in: Cell stem cell, Vol. 21, Issue 3, pp. 359-373.e5, (2017) (PubMed).
Han, Wu: "Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt." in: The Journal of biological chemistry, Vol. 280, Issue 25, pp. 24053-63, (2005) (PubMed).
Funk, Furci, FitzGerald, Grygorczyk, Rochette, Bayne, Abramovitz, Adam, Metters: "Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype." in: The Journal of biological chemistry, Vol. 268, Issue 35, pp. 26767-72, (1994) (PubMed).
Aliases for PTGER1 抗体
prostaglandin E receptor 1 (PTGER1) 抗体 prostaglandin E receptor 1 (Ptger1) 抗体 prostaglandin E receptor 1 (subtype EP1), 42kDa (PTGER1) 抗体 prostaglandin E receptor 1 (subtype EP1) (Ptger1) 抗体 42kDa 抗体 EP1 抗体 PTGER1 抗体 Ptgerep1 抗体