The protein encoded by this gene is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses. [provided by RefSeq, Jul 2008].
Dash, Ghatak, Topi, Satapathy, Ek, Hellman, Olsson, Mehdawi, Sjölander: "High PGD2 receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model." in: British journal of cancer, Vol. 126, Issue 4, pp. 586-597, (2022) (PubMed).
Boie, Sawyer, Slipetz, Metters, Abramovitz: "Molecular cloning and characterization of the human prostanoid DP receptor." in: The Journal of biological chemistry, Vol. 270, Issue 32, pp. 18910-6, (1995) (PubMed).