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PSD10 Protein (AA 1-226, full length) (His-SUMO Tag)

This Recombinant PSD10 protein is expressed in 大肠杆菌(E. Coli).
产品编号 ABIN5710171
发货至: 中国

Quick Overview for PSD10 Protein (AA 1-226, full length) (His-SUMO Tag) (ABIN5710171)

抗原

PSD10 (26S Proteasome Non-ATPase Regulatory Subunit 10 (PSD10))

蛋白类型

Recombinant

宿主

资源

大肠杆菌(E. Coli)

应用范围

SDS-PAGE (SDS)

纯度

> 90 %
  • 产品特性

    full length, AA 1-226

    标记

    This PSD10 protein is labelled with His-SUMO Tag.

    序列

    MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEG

    纯化方法

    SDS-PAGE
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  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.1-2 mg/mL

    缓冲液

    20 mM Tris-HCl based buffer, pH 8.0

    储存条件

    -80 °C,4 °C,-20 °C

    储存方法

    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 抗原

    PSD10 (26S Proteasome Non-ATPase Regulatory Subunit 10 (PSD10))

    别名

    PSD10

    背景

    Acts as a chaperone during the assbly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assbly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assbles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.

    分子量

    40.41 kDa

    UniProt

    O75832
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