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IL-2 蛋白

This not_set IL-2 protein is expressed in 大肠杆菌（E. Coli） and has been mentioned in 2+ publications.

(2 references)

产品编号 ABIN988052

发货至: 中国

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Quick Overview for IL-2 蛋白 (ABIN988052)

抗原

See all IL-2 (IL2) 蛋白

IL-2 (IL2) (Interleukin 2 (IL2))

生物活性

Active

宿主

小鼠

资源

大肠杆菌（E. Coli）

纯度

> 95 % by SDS-PAGE and HPLC analyses.

Discover our top product IL2 蛋白

序列

APTSSSTSSS TAEAQQQQQQ QQQQQQHLEQ LLMDLQELLS RMENYRNLKL PRMLTFKFYL PKQATELKDL QCLEDELGPL RHVLDLTQSK SFQLEDAENF ISNIRVTVVK LKGSDNTFEC QFDDESATVV DFLRRWIAFC QSIISTSP

产品特性

The ED50 as determined by the dose dependent stimulation of murine CTLL-2 cells is < 0.2 ng/ml, corresponding to a specific activity of > 5.0 x 106 units/mg.

内毒素水平

Level Less than 1EU/µg of rMuIL-2 as determined by LAL method
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Interleukin 2 (IL2) (AA 21-153) protein
IL2 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Interleukin 2 (IL2) protein (His tag)
IL2 宿主: 人宿主: HEK-293 Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE.

Interleukin 2 (IL2) (AA 21-169) protein (His-Avi Tag)
IL2 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Interleukin 2 (IL2) (AA 21-169) protein (His-Avi Tag,Biotin)
IL2 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE

Interleukin 2 (IL2) (AA 21-153) protein (mFc Tag)
IL2 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Interleukin 2 (IL2) (Active) protein
IL2 宿主: 大鼠宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active

Interleukin 2 (IL2) (Active) protein
IL2 宿主: 小鼠宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by reducing SDS-PAGE. Active

Interleukin 2 (IL2) (AA 21-153) (Active) protein
IL2 宿主: 人宿主: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active

Interleukin 2 (IL2) (AA 21-153) protein (His tag)
IL2 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Interleukin 2 (IL2) (AA 21-153) (Active) protein (Fc Tag,AVI tag,Biotin)
IL2 宿主: 人宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active

限制

仅限研究用
状态

Lyophilized

溶解方式

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at

储存条件

4 °C
Phuan, Ratelade, Rossi, Tradtrantip, Verkman: "Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arrays." in: The Journal of biological chemistry, Vol. 287, Issue 17, pp. 13829-39, (2012) (PubMed).

Brewin, Mancao, Straathof, Karlsson, Samarasinghe, Amrolia, Pule: "Generation of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative disease." in: Blood, Vol. 114, Issue 23, pp. 4792-803, (2009) (PubMed).
抗原

IL-2 (IL2) (Interleukin 2 (IL2))

别名

Interleukin-2 (IL-2 )

背景

Mature mouse IL-2 shares 56% and 73% aa sequence identity with human and rat IL-2, respectively. It shows strain-specific heterogeneity in an N-terminal region that contains a poly-glutamine stretch. Mouse and human IL-2 exhibit cross-species activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes . The 55 kDa IL-2 Rªis specific for IL-2 and binds with low affinity. The 75 kDa IL-2 Rbeta, which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. The 64 kDa common gamma chainÎ³c/IL-2 RÎ³, which is shared with the receptors for IL-4, -7, -9, -15, and -21, does not independently interact with IL-2. Upon ligand binding, signal transduction is performed by both IL-2 RbetaandÎ³c. It drives resting T cells to proliferate and induces IL-2 and IL-2 Rªsynthesis. It contributes to T cell homeostasis by promoting the Fas-induced death of naÃ¯ve CD4+ T cells but not activated CD4+ memory lymphocytes . IL-2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells. Synonym: Interleukin-2 ( IL-2 ), Mouse. Formulation: Lyophilized from a 0.2µm filtered solution in PBS, pH 7.4.

分子量

Approximately 17.2 kDa, a single non-glycosylated polypeptide chain containing 149 amino acids.

途径

JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation