Fully biologically active when compared to standard. The ED50 determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 15 ng/ml, corresponding to a specific activity of >, 6.7 × 104 IU/mg.
内毒素水平
Level Less than 1EU/µg of rHuIL-17F as determined by LAL method
IL17F
宿主: 大鼠
宿主: Baculovirus infected Insect Cells
Recombinant
> 90 % as determined by SDS-PAGE
Active
限制
仅限研究用
状态
Lyophilized
溶解方式
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 4 mM HCl to a concentration of 0.1mg/ml. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
4 °C
抗原
IL17F
(Interleukin 17F (IL17F))
别名
Interleukin-17F (IL-17F)
背景
Human IL-17F is synthesized as a 153 aa precursor with a 20 aa signal sequence and a 133 aa mature region. Like IL-17A, IL-17F contains one potential site for N-linked glycosylation. IL-17A and IL-17F share 50% aa sequence identity. IL17-F homodimer is produced by an activated subset of CD4+ T cells, termed Th17. IL17-F has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. Synonym: Interleukin-17F (IL-17F), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.
分子量
A disulfide-linked homodimer of 30.1kDa, consisting of two 134 amino acid polypeptide chains.