IL13 Variant (Active) 蛋白
This not_set IL13 Variant protein is expressed in 大肠杆菌（E. Coli）.
产品编号 ABIN988038
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for IL13 Variant (Active) 蛋白 (ABIN988038)
抗原
IL13 Variant
生物活性
Active
宿主
人
资源
大肠杆菌（E. Coli）
纯度
> 95 % by SDS-PAGE and HPLC analyses.
-
-
序列
- SPGPVPPSTA LRELIEELVN ITQNQKAPLC NGSMVWSINL TAGMYCAALE SLINVSGCSA IEKTQRMLSG FCPHKVSAGQ FSSLHVRDTK IEVAQFVKDL LLHLKKLFRE GQF
-
产品特性
- Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent proliferation of TF-1 cells was < 1.0 ng/ml, corresponding to a specific activity of > 1×106 units/mg. This analog has also been shown to exhibit increased in vivo activity compared to wild type IL-13.
-
内毒素水平
- Level Less than 1EU/µg of rHuIL-13 variant as determined by LAL method
-
-
-
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
-
储存条件
- 4 °C
-
-
- IL13 Variant
-
别名
- Interleukin-13 Variant (IL-13 V)
-
背景
- The human IL-13 cDNA encodes a 132 amino acid protein containing a proposed 20 amino acid signal peptide. Human IL-13 shares approximately 30% amino acid sequence homology to human IL-4 and the two cytokines exhibit overlapping biological activities. Human IL-13 is produced by activated Th0, Th1-like Th2-like and CD8 T cells. Similarly to IL-4, IL-13 has multiple effects on the differentiation and functions of monocytes/macrophages. IL-13 can suppress the cytotoxic functions of monocytes/macrophages. It can also suppress the production of proinflammatory cytokines and upregulate the production of IL-1ra by monocytes/macrophages. Synonym: Interleukin-13 Variant ( IL-13 V), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.2, containing 5% trehalose.
-
分子量
- Approximately 12.5 kDa, a single non-glycosylated polypeptide chain containing 114 amino acids, with a substitution of Q for R at position 112 compared with the wild type IL-13.
抗原
-
You are here:
