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Exendin 4 蛋白

This Recombinant Exendin 4 protein is expressed in 大肠杆菌(E. Coli).
产品编号 ABIN987837
发货至: 中国

Quick Overview for Exendin 4 蛋白 (ABIN987837)

抗原

Exendin 4

蛋白类型

Recombinant

生物活性

Active

宿主

Gila monster

资源

大肠杆菌(E. Coli)

纯度

> 96 % by SDS-PAGE and HPLC analyses.
  • 序列

    HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPP

    产品特性

    1. Regulates Glucose levels rapidly 2. Reduces Insulin resistence 3. Reduces Glucagon 4. Reduces HbA1c 5. Stimulates beta cell growth which stimulates insulin production.

    内毒素水平

    Level Less than 10EU/mg of rExendin-4 as determined by LAL method
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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

    储存条件

    4 °C
  • 抗原

    Exendin 4

    别名

    Exendin-4

    背景

    Exendin-4 is a novel 39-amino acid peptide isolated from the venom of the Gila monster Heloderma suspectum. It shares 53% sequence homology with GLP-17-36amide and interacts with the same membrane receptor. Exendin-4 enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying in vivo. It also promotes ß-cell proliferation and neogenesis in vitro and in animal models. Recombinant Exendin-4 is E. coli expression of a synthetic DNA squence encoding the 39 amino acid of Exendin-4. Synonym: Exendin-4. Formulation: Lyophilized from a 0.2um filtered solution of 20mM PBS, pH 7.0, containing 4% mannitol.

    分子量

    Approximately 4.2 kDa, a single non-glycosylated polypeptide chain containing 39 amino acids.
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