beta 2 Defensin 蛋白
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北京 101111
Quick Overview for beta 2 Defensin 蛋白 (ABIN987770)
抗原
See all beta 2 Defensin (BD-2) 蛋白生物活性
宿主
资源
纯度
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序列
- GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK
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产品特性
- Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay usingimmature human dendritic cells is less than 100 ng/ml, corresponding to a specific activity of >, 1.0 × 104 IU/mg.
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内毒素水平
- Level Less than 1EU/µg of rHuBD-2 as determined by LAL method
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Defensin beta 2 (BD-2) (AA 21-71) protein (His-IF2DI Tag)
BD-2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Defensin beta 2 (BD-2) (Active) proteinBD-2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, STD, PI Active
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
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储存条件
- 4 °C
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- beta 2 Defensin (BD-2) (Defensin beta 2 (BD-2))
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别名
- beta-Defensin 2 (BD-2)
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背景
- Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The ª-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified, BD-1, BD-2, BD-3 and BD-4. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. beta-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. Synonym: beta-Defensin 2 (BD-2), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 130mM NaCl.
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分子量
- Approximately 4.3 KDa, a single non-glycosylated polypeptide chain containing 41 amino acids.
抗原
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