HRG1 beta (Active) 蛋白
This Recombinant protein is expressed in 大肠杆菌（E. Coli）.
Quick Overview for HRG1 beta (Active) 蛋白 (ABIN935431)
抗原
HRG1 beta
蛋白类型
Recombinant
生物活性
Active
宿主
人
资源
大肠杆菌（E. Coli）
纯度
> 98 % pure
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序列
- SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
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产品特性
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Purified recombinant Human HRG1 beta protein
Expression System: E.coli
Bioactivity: The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ? 0.5 ng/mL, corresponding to a specific activity of ? 2 x 10^6 units/mg. -
内毒素水平
- < 0.1 ng per μg (1 EU/μg).
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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说明
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Biological activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is approx. 0.5 ng/mL, corresponding to a specific activity of approx. 2 x 10^6 units/mg.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitute in water to a concentration of 0.1 - 1.0 mg/mL.
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缓冲液
- Supplied lyophilized with no additives.
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储存液
- Without preservative
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- RT/-20 °C
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- HRG1 beta
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背景
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Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-beta1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation.
Alternative Names: Neuregulin1 protein, HRG beta 1 protein, HRG1 beta, Neu differentiation factor protein, HRG beta-1 protein, HRG beta 1, HRG beta-1, Heregulin 1 protein, NRG1-beta1 protein
抗原
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