Bacillus anthracis 蛋白
This Recombinant Bacillus anthracis protein is expressed in 大肠杆菌（E. Coli）.
Quick Overview for Bacillus anthracis 蛋白 (ABIN935200)
抗原
Bacillus anthracis
蛋白类型
Recombinant
宿主
Bacillus anthracis
资源
大肠杆菌（E. Coli）
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产品特性
- Purified recombinant Bacillus Anthracis (Anthrax) protein (Protective Antigen)
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized from 10 mM BIS-Tris propane, pH 8.5, with 1.25 % trehalose.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- 4 °C
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储存方法
- Store at 4 °C.
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- Bacillus anthracis
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物质类
- Bacteria
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背景
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PA63 is the carboxyl-terminal 63- kDa fragment obtained by the proteolytic cleavage of the receptor-bound protective antigen (PA), one of the three proteins that comprise anthrax toxin. Unlike native PA, PA 63 oligomerizes to form a ring-shaped heptamer that binds up to three copies of EF and/or LF competitively and with high affinity (kDa ~1 nM). Whereas native PA persists on the cell surface, the heptamer is endocytosed, presumably because oligomerization aggregates anthrax toxin receptor. The endocytosed toxic complexes are trafficked to endosomal compartments where the low pH causes the PA63 heptamer to insert into the membrane and form a water-filled channel.
Alternative Names: Bacillus Anthracis Protein, Bacillus anthracis Protective Nicked Antigen, Anthrax Protein, Recombinant B Anthracis -
分子量
- 63 kDa
抗原
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