Ataxin 3 Protein (ATXN3) (AA 1-370)
Quick Overview for Ataxin 3 Protein (ATXN3) (AA 1-370) (ABIN935045)
抗原
See all Ataxin 3 (ATXN3) 蛋白蛋白类型
宿主
资源
应用范围
纯度
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产品特性
- AA 1-370
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序列
- MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RVLEANDGSG MLDEDEEDLQ RALALSRQEI DMEDEEADLR RAIQLSMQGS SRNISQDMTQ TSGTNLTSEE LRKRREAYFE KQQQKQQQQQ QQQQQQQQQQ QQQQGDLSGQ SSHPCERPAT SSGALGSDLG DAMSEEDMLQ AAVTMSLETV RNDLKTEGKK
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产品特性
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Purified recombinant Human Ataxin 3 protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher. -
内毒素水平
- < 1.0 EU per µg of protein (determined by LAL method)
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Ataxin 3 (ATXN3) (AA 1-355) protein (His tag)
custom-made ATXN3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Ataxin 3 (ATXN3) (AA 1-79) protein (GST tag)ATXN3 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Ataxin 3 (ATXN3) (AA 1-370) protein (GST tag)ATXN3 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Ataxin 3 (ATXN3) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)ATXN3 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Ataxin protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Supplied as a liquid in 20 mM Tris-HCl buffer, pH 7.5, containing 0 mM DTT, 50 mM NaCl, and 10 % glycerol.
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储存液
- Dithiothreitol (DTT)
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注意事项
- This product contains Dithiothreitol: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- RT/-20 °C
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储存方法
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
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- Ataxin 3 (ATXN3)
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别名
- Ataxin 3
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背景
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Ataxin 3 is also known as Machado-Joseph disease protein 1. Machado-Joseph disease is one of several hereditary autosomal dominant neurodegenerative disorders. This protein contains trinucleotide CAG repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. Ataxin 3 interacts with the major histone acetyltransferases cAMP-response-element binding protein (CREB)-binding protein, p300, and p300/CREB-binding protein-associated factor and inhibits transcription by these coactivators. Also, ataxin-3 is a proteasome-associated factor that mediates the degradation of ubiquitinated proteins. Recombinant human Ataxin-3 was expressed in E. coli and purified by using conventional chromatography.
Alternative Names: Machado-Joseph disease protein 1 homolog protein, Machado Joseph disease protein, AT3 protein, JOS protein, MJD1 protein, MJD gene protein, Machado Joseph disease protein 1 protein, EC 3.4.22. protein, ATXN3 protein, , Spinocerebellar ataxia type 3 protein protein, Rsca3 protein, MJD protein, Josephin protein, ATX3 protein, ATXN3 protein, SCA3 protein, Ataxin 3 protein, SCA3 gene protein -
分子量
- 42.4 kDa (370 AA)
抗原
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