Quick Overview for STUB1 Protein (AA 1-303) (ABIN935009)
抗原
See all STUB1 蛋白蛋白类型
宿主
资源
应用范围
纯度
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产品特性
- AA 1-303
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序列
- MKGKEEKEGG ARLGAGGGSP EKSPSAQELK EQGNRLFVGR KYPEAAACYG RAITRNPLVA VYYTNRALCY LKMQQHEQAL ADCRRALELD GQSVKAHFFL GQCQLEMESY DEAIANLQRA YSLAKEQRLN FGDDIPSALR IAKKKRWNSI EERRIHQESE LHSYLSRLIA AERERELEEC QRNHEGDEDD SHVRAQQACI EAKHDKYMAD MDELFSQVDE KRKKRDIPDY LCGKISFELM REPCITPSGI TYDRKDIEEH LQRVGHFDPV TRSPLTQEQL IPNLAMKEVI DAFISENGWV EDY
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产品特性
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Purified recombinant Human CHIP protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher. -
内毒素水平
- < 1.0 EU per µg of protein (determined by LAL method)
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STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-304) protein (His tag)
custom-made STUB1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (His tag)custom-made STUB1 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (His tag)STUB1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (GST tag)STUB1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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应用备注
- CHIP protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Supplied as a liquid in 20 mM Tris-HCl buffer, pH 7.5, containing 0 mM DTT, and 10 % glycerol.
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储存液
- Dithiothreitol (DTT)
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注意事项
- This product contains Dithiothreitol: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- RT/-20 °C
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储存方法
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
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- STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
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别名
- CHIP
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背景
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CHIP, also known as STUB1, is a cytoplasmic protein whose amino acid sequence is highly conserved across species. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, whereas its U-box domain contains its E3 ubiquitin ligase activity. Its interaction with these molecular chaperones results in client substrate ubiquitylation and degradation by the proteasome. Thus, CHIP acts to tilt the folding-refolding machinery toward the degradative pathway, and it serves as a link between the two. Recombinant human CHIP protein was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: NY CO 7 protein, STUB 1 protein, CHIP protein, HSPABP2 protein, STIP1 homology and U Box containing protein 1., E3 ubiquitin protein ligase CHIP protein, STUB1 protein, UBOX1 protein, Carboxy terminus of HSP70 interacting protein protein NY CO 7 protein, SDCCAG7 protein, UBOX 1 protein, NY-CO-7 protein, Carboxy terminus of Hsp70p interacting protein protein, Serologically defined colon cancer protein 7 protein, CLL associated protein KW 8 protein, Heat shock protein A binding protein 2 (c terminal) protein -
分子量
- 34.8 kDa (303 AA)
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途径
- Regulation of Hormone Metabolic Process, Response to Water Deprivation
抗原
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