MMP2 Protein (AA 30-660)
Our Local Distributor
北京 101111
Quick Overview for MMP2 Protein (AA 30-660) (ABIN8057040)
抗原
See all MMP2 蛋白蛋白类型
宿主
资源
应用范围
纯度
-
-
产品特性
- AA 30-660
-
原理
- Recombinant Human MMP-2 Protein(Halo Tag)
-
序列
- Ala30-Cys660
-
过滤
- 0.2 μm filtered
-
内毒素水平
- < 1.0 EU/mg of the protein as determined by the LAL method
-
Biological Activity Comment
- Not validated for activity
-
-
Matrix Metalloproteinase 2 (MMP2) (Active) protein
MMP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Matrix Metalloproteinase 2 (MMP2) (AA 30-660) protein (His tag)MMP2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Matrix Metalloproteinase 2 (MMP2) (AA 424-660) protein (His-IF2DI Tag)MMP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Matrix Metalloproteinase 2 (MMP2) (AA 109-660) protein (His-IF2DI Tag)MMP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Matrix Metalloproteinase 2 (MMP2) (AA 1-660) protein (GST tag)MMP2 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
-
缓冲液
- Lyophilized from a 0.2 μm filtered solution in PBS with 5 % Trehalose and 5 % Mannitol.
-
储存条件
- 4 °C,-20 °C,-80 °C
-
储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
有效期
- 12 months
-
-
- MMP2 (Matrix Metalloproteinase 2 (MMP2))
-
别名
- MMP-2
-
背景
- Gelatinase A,72 kDa type IV collagenase,Matrix metalloproteinase-2,TBE-1,Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.
-
分子量
-
Calculated MW: 103.3 kDa
Observed MW: 100-110 kDa
-
基因ID
- 4313
-
UniProt
- P08253
-
途径
- Activation of Innate immune Response
抗原
-
